Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032801 | 0.77 | CYP2A6 (0.42) | — | |
| SCHEMBL8048177 | 0.74 | RAB9A (0.37) | — | |
| SCHEMBL9773323 | 0.73 | CES1 (0.40) | NEK2PLK1NEK1 | |
| SCHEMBL15972026 | 0.65 | NEK2 (0.34) | NEK2PLK1NEK1 | |
| SCHEMBL2120265 | 0.65 | TP53 (0.42) | — | |
| SCHEMBL8042926 | 0.64 | MEN1 (0.34) | — | |
| SCHEMBL15971983 | 0.63 | S1PR4 (0.35) | NEK2PLK1NEK1 | |
| SCHEMBL4583876 | 0.62 | ADORA1 (0.41) | — | |
| SCHEMBL8802233 | 0.61 | NEK2 (0.33) | NEK2PLK1NEK1 | |
| SCHEMBL19351463 | 0.61 | KEAP1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |