Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 12/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7114230 | 0.75 | FBP1 (0.70) | FBP1PDK1ALDH1A1HTR7FDPS | |
| SCHEMBL8048536 | 0.74 | FBP1 (0.47) | FBP1PDK1ALDH1A1HTR7 | |
| SCHEMBL8043078 | 0.74 | FBP1 (0.47) | FBP1PDK1ALDH1A1HTR7GABRA1 | |
| SCHEMBL8045097 | 0.72 | RAB9A (0.35) | ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL8043975 | 0.72 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL8046775 | 0.70 | FBP1 (0.42) | FBP1PDK1ALDH1A1HTR7FDPS | |
| SCHEMBL8047678 | 0.70 | FBP1 (0.42) | FBP1PDK1ALDH1A1HTR7FDPS | |
| SCHEMBL8048705 | 0.70 | FBP1 (0.46) | FBP1PDK1ALDH1A1HTR7FDPS | |
| SCHEMBL13814464 | 0.69 | ALDH1A1 (0.50) | FBP1ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL8045096 | 0.68 | PDPK1 (0.51) | FBP1PDK1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |