Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033751 | 0.83 | RXRA (0.43) | RXRARXRBRXRGHCAR2MEN1 | |
| SCHEMBL8050732 | 0.80 | RXRA (0.43) | RXRARXRBRXRGHCAR2ALDH1A1 | |
| SCHEMBL8042980 | 0.80 | ALDH1A1 (0.41) | RXRARXRBRXRGHCAR2CYP2C19 | |
| SCHEMBL8042151 | 0.79 | CYP1A2 (0.37) | CYP1A2CYP2C9CYP2C19CYP2D6MEN1 | |
| SCHEMBL8042788 | 0.78 | HSD17B10 (0.42) | RXRARXRBRXRGHCAR2CYP2C19 | |
| SCHEMBL8041806 | 0.77 | KMT2A (0.38) | RXRARXRBRXRGHCAR2MEN1 | |
| SCHEMBL8048331 | 0.77 | ALDH1A1 (0.33) | CYP1A2CYP2C9CYP2C19CYP2D6MEN1 | |
| SCHEMBL8045818 | 0.77 | HPGD (0.51) | MEN1KMT2AALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8046081 | 0.76 | ALDH1A1 (0.46) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL8046585 | 0.76 | RXRA (0.43) | RXRARXRBRXRGHCAR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |