Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042980 | 0.87 | ALDH1A1 (0.41) | KMT2ANPC1RXRARXRBRXRG | |
| SCHEMBL8042788 | 0.85 | HSD17B10 (0.42) | KMT2ANPC1RXRARXRBRXRG | |
| SCHEMBL8051020 | 0.85 | KDM4C (0.38) | KMT2ANPC1KDM4CALDH1A1HPGD | |
| SCHEMBL8033764 | 0.83 | HTT (0.46) | KMT2ARXRARXRBRXRGALDH1A1 | |
| SCHEMBL8046221 | 0.83 | ALDH1A1 (0.51) | KMT2AALDH1A1HPGDMAPK1MAPT | |
| SCHEMBL8050401 | 0.81 | KMT2A (0.36) | KMT2ANPC1KDM4CALDH1A1HPGD | |
| SCHEMBL8050397 | 0.81 | ALDH1A1 (0.40) | KMT2ARXRARXRBRXRGKDM4C | |
| SCHEMBL8032474 | 0.81 | NPC1 (0.47) | KMT2ANPC1KDM4CALDH1A1HPGD | |
| SCHEMBL8043875 | 0.80 | UBE2M (0.37) | RXRARXRBRXRGALDH1A1HPGD | |
| SCHEMBL8716288 | 0.80 | CYP2C19 (0.47) | KMT2ARXRARXRBRXRGALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |