Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046664 | 0.83 | CA12 (0.42) | ALDH1A1SMN1; SMN2POLBCYP2C19MEN1 | |
| SCHEMBL8041836 | 0.81 | ALDH1A1 (0.42) | ALDH1A1GAANPC1SMN1; SMN2RAB9A | |
| SCHEMBL8044376 | 0.80 | CA12 (0.33) | USP2 | |
| SCHEMBL8042151 | 0.79 | CYP1A2 (0.37) | ALDH1A1GAANPC1SMN1; SMN2RAB9A | |
| SCHEMBL8045938 | 0.79 | HSD17B10 (0.40) | ALDH1A1GAANPC1SMN1; SMN2RAB9A | |
| SCHEMBL8044808 | 0.77 | RXRA (0.40) | ALDH1A1GAANPC1SMN1; SMN2RAB9A | |
| SCHEMBL8033250 | 0.77 | HTT (0.41) | ALDH1A1GAAPOLBCYP1A2CYP2D6 | |
| SCHEMBL8048309 | 0.77 | ALDH1A1 (0.52) | ALDH1A1GAASMN1; SMN2POLBMEN1 | |
| SCHEMBL8050401 | 0.77 | KMT2A (0.36) | ALDH1A1NPC1SMN1; SMN2KMT2A | |
| SCHEMBL8033930 | 0.76 | ALDH1A1 (0.39) | ALDH1A1GAASMN1; SMN2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |