Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870482 | 0.80 | HSD17B10 (0.62) | HSD17B10POLBRXFP1ALDH1A1NPC1 | |
| SCHEMBL8045460 | 0.77 | SMN1; SMN2 (0.39) | ALDH1A1NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL3892022 | 0.75 | HSD17B10 (0.53) | HSD17B10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL13162542 | 0.71 | HSD17B10 (0.59) | HSD17B10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL7402835 | 0.71 | CYP1A2 (0.63) | HSD17B10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL27044923 | 0.70 | HSD17B10 (0.62) | HSD17B10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL15562974 | 0.67 | MAPT (0.55) | HSD17B10POLBALDH1A1NPC1RAB9A | |
| SCHEMBL11686013 | 0.67 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL7153877 | 0.65 | L3MBTL1 (0.60) | HSD17B10POLBRXFP1ALDH1A1MAPT | |
| SCHEMBL27676047 | 0.65 | HSD17B10 (0.44) | HSD17B10POLBALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001969-A1 | PEPTIDOMIMETIC DERIVATIVES SUICIDAL INHIBITORS OF THE HIV PROLIFERATION | ZAMBON GROUP S.p.A. (IT) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001470-A2 | PEPTIDOMIMETIC DERIVATIVES SUICIDAL INHIBITORS OF THE HIV PROLIFERATION | ZAMBON GROUP S.P.A. (IT) | 1999-01-14 | — | — | WO | disclosed |