Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042112 | 0.86 | CSNK1D (0.39) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8044044 | 0.86 | KMT2A (0.45) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8044738 | 0.86 | CSNK1D (0.39) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8044955 | 0.86 | USP2 (0.48) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8050255 | 0.85 | MAPT (0.46) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8043994 | 0.85 | ALDH1A1 (0.53) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8048043 | 0.84 | CPB1 (0.43) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8051920 | 0.84 | TSHR (0.51) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8046376 | 0.81 | SMN1; SMN2 (0.41) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8043947 | 0.79 | TSHR (0.44) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |