Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 3/20 | 0.52 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.50 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432918 | 0.84 | CBX7 (0.47) | MAT2AGRIN1GRIN2BHDAC1HDAC8 | |
| SCHEMBL7301671 | 0.84 | MAT2A (0.48) | MAT2AKMOMCL1HDAC6 | |
| SCHEMBL8890567 | 0.83 | HDAC1 (0.47) | AKR1B1AKR1A1GRIN2DGRIN3BGRIA1 | |
| SCHEMBL640508 | 0.82 | CBX7 (0.58) | AKR1B1PTGDR2KMOGRIN2DGRIN3B | |
| SCHEMBL7660613 | 0.82 | ALDH1A1 (0.49) | MAT2ACBX7CDYL2CDYLCDY1; CDY1B | |
| SCHEMBL8488740 | 0.81 | MAT2A (0.47) | MAT2AAKR1B1AKR1A1AKR1B10HDAC1 | |
| SCHEMBL8377270 | 0.79 | KDM4E (0.64) | AKR1B1AKR1B10 | |
| SCHEMBL7309368 | 0.78 | MAT2A (0.44) | MAT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL12822337 | 0.77 | MAT2A (0.65) | MAT2AHDAC1HDAC8HDAC6 | |
| SCHEMBL8893031 | 0.77 | GRIN2D (0.48) | AKR1B1PTGDR2AKR1A1AKR1B10KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | claimed |
| EP-0847392-B1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | CLARIANT GMBH (DE) | 1999-12-08 | — | — | EP | claimed |
| EP-1010695-A1 | PROCESS FOR PRODUCING QUINAZOLINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-06-21 | — | — | EP | disclosed |
| EP-0789020-B1 | Process for producing dioxoquinazolines | SUMITOMO CHEMICAL CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-6001831-A | Process for producing quinazoline derivatives | CLARIANT GMBH (DE) | 1999-12-14 | — | — | US | disclosed |
| EP-0789020-A1 | Process for producing dioxoquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-08-13 | — | — | EP | disclosed |