Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMO | O15229 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TYMP | P19971 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299674 | 0.90 | KDM4E (0.48) | KDM4EHSD17B10MAPK1KMOGAA | |
| SCHEMBL7309368 | 0.84 | MAT2A (0.44) | MAT2AHPGDHDAC6ALDH1A1TYMP | |
| SCHEMBL8046411 | 0.84 | MAT2A (0.52) | MAT2AKMOHDAC6MCL1 | |
| SCHEMBL7309296 | 0.83 | TDP1 (0.47) | MAT2AKDM4EHSD17B10GAAHPGD | |
| SCHEMBL7302539 | 0.83 | MAT2A (0.44) | MAT2ATYMP | |
| SCHEMBL7651696 | 0.82 | MAT2A (0.44) | MAT2AHDAC6TYMP | |
| SCHEMBL7300140 | 0.81 | FABP4 (0.68) | KDM4EHSD17B10MAPK1HPGDFABP4 | |
| SCHEMBL7026263 | 0.78 | ALDH1A1 (0.48) | MAT2AKDM4EHDAC6ALDH1A1BCL2L1 | |
| SCHEMBL16147632 | 0.75 | FABP4 (0.61) | KMOFABP4FABP5OXER1 | |
| SCHEMBL8432918 | 0.74 | CBX7 (0.47) | MAT2AKDM4EHDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304560-A | Treating CNS disorders; dopamine receptor antagonist | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| EP-0481342-A1 | Quinazoline derivatives and their preparation | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |