Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | GCK | P35557 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CBLB | Q13191 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032536 | 0.76 | RAB9A (0.56) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8044478 | 0.75 | MEN1 (0.40) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8046692 | 0.74 | ABL1 (0.44) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8046497 | 0.74 | HSD17B10 (0.43) | HSD17B10GCKKDM4EALDH1A1POLB | |
| SCHEMBL8050834 | 0.73 | GCK (0.46) | HSD17B10GCKALDH1A1CBLBLMNA | |
| SCHEMBL8042838 | 0.73 | SMN1; SMN2 (0.50) | HSD17B10MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8043093 | 0.71 | SMN1; SMN2 (0.38) | GCKPOLBRAB9ACBLBSMN1; SMN2 | |
| SCHEMBL8041800 | 0.71 | HSD17B10 (0.34) | HSD17B10GCKMEN1KMT2AKDM4E | |
| SCHEMBL8034370 | 0.70 | MEN1 (0.37) | MEN1KMT2AALDH1A1POLBRAB9A | |
| SCHEMBL8045340 | 0.69 | KDM4E (0.63) | HSD17B10MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |