Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MIF | P14174 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046525 | 0.86 | TSHR (0.49) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8048230 | 0.83 | KDM4E (0.43) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8043400 | 0.83 | ALDH1A1 (0.53) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8044219 | 0.83 | TSHR (0.38) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8044988 | 0.82 | KDM4E (0.58) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8042595 | 0.82 | RAB9A (0.47) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8044774 | 0.81 | KDM4E (0.43) | TSHRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8050831 | 0.80 | HSP90AA1 (0.46) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8051653 | 0.80 | TSHR (0.41) | TSHRMEN1KMT2AKDM4EUSP2 | |
| SCHEMBL8050800 | 0.79 | HTR1A (0.49) | TSHRKMT2AKDM4EUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |