Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047497 | 0.81 | KIF11 (0.45) | KIF11TDP1NISCHTP53NOTUM | |
| SCHEMBL8048034 | 0.79 | KIF11 (0.49) | KIF11 | |
| SCHEMBL8042073 | 0.71 | MAPT (0.43) | KIF11KDM4EPOLBAPOBEC3GTDP1 | |
| SCHEMBL26915 | 0.68 | KIF11 (0.70) | KIF11ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3423876 | 0.68 | KIF11 (0.70) | KIF11ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13196502 | 0.67 | KIF11 (0.45) | KIF11ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1931781 | 0.66 | KIF11 (0.67) | KIF11ALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL14008987 | 0.65 | KIF11 (0.44) | KIF11ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8043935 | 0.65 | RXRA (0.33) | — | |
| SCHEMBL424728 | 0.65 | TSHR (0.73) | KIF11ALDH1A1HPGDHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |