Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041917 | 0.82 | CTSS (0.44) | IKBKB | |
| SCHEMBL8047497 | 0.81 | KIF11 (0.45) | — | |
| SCHEMBL8043481 | 0.70 | CES2 (0.38) | CES2 | |
| SCHEMBL8046152 | 0.69 | CHRNB4 (0.31) | — | |
| SCHEMBL8044653 | 0.69 | BACE1 (0.35) | — | |
| SCHEMBL9482063 | 0.68 | RXRA (0.54) | RXRARXRBRXRGIKBKBCES2 | |
| SCHEMBL13866628 | 0.66 | RXRA (0.52) | RXRARXRBRXRGIKBKBCES2 | |
| SCHEMBL19099829 | 0.65 | ADRB1 (0.34) | RXRARXRBRXRGIKBKBCES2 | |
| SCHEMBL8047010 | 0.65 | KIF11 (0.44) | — | |
| SCHEMBL440959 | 0.65 | CES2 (0.58) | RXRARXRBRXRGCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |