Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14647198 | 0.85 | MAPK1 (0.44) | TAS1R3TAS1R1CRHR1LMNAMAPT | |
| SCHEMBL25059485 | 0.79 | RAPGEF4 (0.43) | KCNH2TAS1R3TAS1R1CRHR1LMNA | |
| SCHEMBL5923925 | 0.77 | TAS1R3 (0.68) | TAS1R3TAS1R1RAB9ALMNAMAPT | |
| SCHEMBL8362209 | 0.76 | RAB9A (0.44) | RAB9ACRHR1LMNAMAPTKMT2A | |
| SCHEMBL24893149 | 0.73 | RAB9A (0.41) | RAB9ACRHR1LMNAMAPTKMT2A | |
| SCHEMBL18893491 | 0.73 | LMNA (0.45) | RAB9ALMNAMAPTKMT2A | |
| SCHEMBL8858024 | 0.72 | CA1 (0.51) | RAB9ALMNAMAPTKMT2AUBE2M | |
| SCHEMBL8293199 | 0.72 | LMNA (0.47) | RAB9ALMNAMAPTKMT2A | |
| SCHEMBL12198284 | 0.70 | KCNH2 (0.34) | KCNH2TAS1R3TAS1R1CRHR1 | |
| SCHEMBL14647143 | 0.70 | POLB (0.39) | KCNH2TAS1R3TAS1R1CRHR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062676-A2 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |