Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | USP2 | O75604 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045952 | 0.84 | TSHR (0.59) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8043994 | 0.82 | ALDH1A1 (0.53) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8043400 | 0.82 | ALDH1A1 (0.53) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8044955 | 0.82 | USP2 (0.48) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8047245 | 0.82 | KDM4E (0.54) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8042533 | 0.82 | HDAC6 (0.53) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8042284 | 0.82 | TSHR (0.56) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8051768 | 0.81 | PDK1 (0.51) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8042817 | 0.81 | ALDH1A1 (0.50) | ALDH1A1USP2HSD17B10KDM4ERAB9A | |
| SCHEMBL8043995 | 0.81 | SMN1; SMN2 (0.53) | ALDH1A1USP2HSD17B10KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |