Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 5/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043693 | 0.78 | PIP4K2C (0.38) | LMNAGCKL3MBTL1CASP6TDP1 | |
| SCHEMBL8033687 | 0.77 | RXRA (0.43) | LMNAGCKL3MBTL1CASP6TDP1 | |
| SCHEMBL7823341 | 0.76 | TDP1 (0.56) | L3MBTL1CASP6TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8032709 | 0.75 | HTT (0.41) | LMNAL3MBTL1TDP1TP53SMN1; SMN2 | |
| SCHEMBL8041815 | 0.72 | MEN1 (0.33) | USP7 | |
| SCHEMBL8050834 | 0.71 | GCK (0.46) | LMNAGCKCBLBHSD17B10ALDH1A1 | |
| SCHEMBL8044080 | 0.70 | ALDH1A1 (0.40) | LMNATP53SMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL8042151 | 0.69 | CYP1A2 (0.37) | TDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8051237 | 0.69 | SMN1; SMN2 (0.30) | SMN1; SMN2 | |
| SCHEMBL8044897 | 0.69 | ALDH1A1 (0.45) | LMNAL3MBTL1TP53SMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |