Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GCK | P35557 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | HBB | P68871 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050654 | 0.79 | NPC1 (0.36) | SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL8046664 | 0.79 | CA12 (0.42) | PIP4K2CALDH1A1HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL8047637 | 0.78 | LMNA (0.39) | PIP4K2CALDH1A1HTTSMN1; SMN2HSD17B10 | |
| SCHEMBL8033687 | 0.76 | RXRA (0.43) | ALDH1A1SMN1; SMN2HSD17B10KDM4EGCK | |
| SCHEMBL8048372 | 0.76 | MEN1 (0.33) | MEN1KMT2A | |
| SCHEMBL7823341 | 0.75 | TDP1 (0.56) | ALDH1A1HTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8045938 | 0.75 | HSD17B10 (0.40) | ALDH1A1HTTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8041836 | 0.74 | ALDH1A1 (0.42) | ALDH1A1HTTSMN1; SMN2HSD17B10MEN1 | |
| SCHEMBL8045587 | 0.73 | — | — | |
| SCHEMBL8048331 | 0.73 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2MEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |