Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.46 |
| ▸ | FBP1 | P09467 | 4/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | CBLB | Q13191 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8038016 | 0.73 | HTT (0.46) | FBP1PDK1HSD17B10LMNAPIP4K2C | |
| SCHEMBL8044648 | 0.73 | HSD17B10 (0.50) | GCKCBLBHSD17B10LMNAALDH1A1 | |
| SCHEMBL8043084 | 0.73 | FBP1 (0.42) | FBP1PDK1HTR7LMNAFLT3 | |
| SCHEMBL8047637 | 0.71 | LMNA (0.39) | GCKCBLBHSD17B10LMNAPIP4K2C | |
| SCHEMBL7114230 | 0.71 | FBP1 (0.70) | FBP1PDK1HTR7HSD17B10FLT3 | |
| SCHEMBL8047257 | 0.70 | FBP1 (0.39) | FBP1PDK1HTR7FLT3KDM1A | |
| SCHEMBL8043181 | 0.69 | KDM4E (0.63) | HSD17B10LMNAALDH1A1 | |
| SCHEMBL19160378 | 0.69 | GCK (0.47) | GCKHSD17B10LMNAPIP4K2CALDH1A1 | |
| SCHEMBL8045352 | 0.68 | ALOX15 (0.41) | FBP1PDK1HTR7HSD17B10LMNA | |
| SCHEMBL8043693 | 0.68 | PIP4K2C (0.38) | GCKHSD17B10LMNAPIP4K2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |