Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033941 | 0.90 | SMN1; SMN2 (0.36) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8042296 | 0.87 | RAB9A (0.39) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8042402 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8044452 | 0.82 | RAB9A (0.44) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8050096 | 0.81 | RAB9A (0.37) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8042050 | 0.80 | LMNA (0.42) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8042936 | 0.80 | RAB9A (0.32) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8051868 | 0.80 | HTR1A (0.52) | SMN1; SMN2RAB9ANPC1GAAMEN1 | |
| SCHEMBL8048046 | 0.77 | MAPT (0.47) | SMN1; SMN2RAB9ANPC1NPSR1POLB | |
| SCHEMBL8050943 | 0.77 | FBP1 (0.42) | SMN1; SMN2LMNATRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |