Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 14/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL747616 | 0.84 | GPR119 (0.54) | RBP4MEN1KMT2AGPR119 | |
| SCHEMBL19139293 | 0.84 | GRM2 (0.45) | RBP4GRM2MEN1KMT2AGPR119 | |
| SCHEMBL6926259 | 0.77 | GRM2 (0.49) | RBP4GRM2 | |
| SCHEMBL6321078 | 0.73 | RBP4 (0.66) | RBP4GPR119CYP2D6CYP2C19 | |
| SCHEMBL13844650 | 0.70 | ALDH1A1 (0.53) | GPR119 | |
| SCHEMBL6589288 | 0.69 | GPR119 (0.49) | RBP4MEN1KMT2AGPR119 | |
| SCHEMBL745921 | 0.69 | HTR2C (0.65) | MEN1KMT2ACYP2D6 | |
| SCHEMBL12943293 | 0.69 | GPR119 (0.55) | MEN1KMT2AGPR119 | |
| SCHEMBL3436365 | 0.69 | GPR119 (0.58) | MEN1KMT2AGPR119 | |
| SCHEMBL7979993 | 0.68 | CHRM2 (0.37) | MEN1KMT2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009062676-A2 | IMIDAZO[1,2-A]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |