Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044826 | 0.87 | PDK1 (0.53) | KMT2AMAPTSMN1; SMN2LMNAHTT | |
| SCHEMBL8044910 | 0.87 | NPC1 (0.43) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8047942 | 0.86 | PKM (0.40) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8042232 | 0.83 | ALDH1A1 (0.50) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8044245 | 0.83 | MEN1 (0.46) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8044412 | 0.82 | SMN1; SMN2 (0.44) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8033619 | 0.82 | PKM (0.40) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8052304 | 0.81 | ALDH1A1 (0.49) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8048328 | 0.79 | PKM (0.41) | KMT2AMAPTSMN1; SMN2LMNATP53 | |
| SCHEMBL8033160 | 0.79 | PKM (0.51) | KMT2AMAPTSMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |