Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.46 |
| ▸ | HPGD | P15428 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | MITF | O75030 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.37 |
| ▸ | RELA | Q04206 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044826 | 0.87 | PDK1 (0.53) | MEN1KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL8047829 | 0.85 | ALDH1A1 (0.40) | MEN1KMT2AHPGDPOLBRECQL | |
| SCHEMBL8046550 | 0.85 | ALDH1A1 (0.40) | MEN1KMT2AHPGDPOLBRECQL | |
| SCHEMBL8042232 | 0.83 | ALDH1A1 (0.50) | MEN1KMT2AHPGDPOLBRECQL | |
| SCHEMBL8050340 | 0.83 | KMT2A (0.46) | MEN1KMT2AHPGDPOLBALDH1A1 | |
| SCHEMBL8033820 | 0.81 | ALDH1A1 (0.49) | MEN1KMT2AHPGDPOLBRECQL | |
| SCHEMBL8042685 | 0.81 | NFKB1 (0.42) | MEN1KMT2AHPGDPOLBRECQL | |
| SCHEMBL8044915 | 0.80 | RECQL (0.54) | MEN1KMT2AHPGDPOLBRECQL | |
| SCHEMBL8044411 | 0.80 | KMT2A (0.55) | MEN1KMT2AHPGDPOLBALDH1A1 | |
| SCHEMBL8052167 | 0.80 | ALDH1A1 (0.41) | MEN1KMT2AHPGDPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |