Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.37 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046773 | 0.84 | PKM (0.41) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8044438 | 0.82 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8052232 | 0.82 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8046037 | 0.80 | NPC1 (0.42) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8042860 | 0.78 | HDAC6 (0.44) | SMN1; SMN2NPSR1HTTL3MBTL1MEN1 | |
| SCHEMBL8045350 | 0.77 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2LMNAHTTTSHR | |
| SCHEMBL8043961 | 0.77 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8043682 | 0.76 | HTT (0.50) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8034272 | 0.76 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT | |
| SCHEMBL8044246 | 0.75 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2NPSR1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |