Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8710516 | 0.89 | RAB9A (0.37) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8046221 | 0.89 | ALDH1A1 (0.51) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8042788 | 0.84 | HSD17B10 (0.42) | ALDH1A1MEN1KMT2ARAB9AHPGD | |
| SCHEMBL8033672 | 0.83 | NPSR1 (0.39) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8033764 | 0.82 | HTT (0.46) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8045074 | 0.81 | RAB9A (0.41) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8044868 | 0.81 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8041806 | 0.81 | KMT2A (0.38) | ALDH1A1MEN1KMT2ATSHRLMNA | |
| SCHEMBL8042980 | 0.81 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2ALMNARAB9A | |
| SCHEMBL8051088 | 0.81 | NPC1 (0.45) | ALDH1A1MEN1KMT2ARAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |