Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042747 | 0.94 | PKM (0.42) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8043670 | 0.90 | PKM (0.44) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8043502 | 0.89 | PKM (0.39) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8041894 | 0.89 | PKM (0.39) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8033934 | 0.85 | ALDH1A1 (0.45) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8033856 | 0.84 | PKM (0.46) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8043976 | 0.84 | KDM4E (0.43) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8042716 | 0.83 | ALDH1A1 (0.52) | PKMSMN1; SMN2LMNAMAPTKMT2A | |
| SCHEMBL8047359 | 0.83 | PDK1 (0.52) | HSP90AA1HSP90AB1SMN1; SMN2LMNAMAPT | |
| SCHEMBL8042861 | 0.82 | HCAR3 (0.48) | PKMHSP90AA1HSP90AB1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |