Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8136531 | 0.94 | HTR1A (0.47) | MEN1KMT2AATMGAATRPV1 | |
| Fumaric Acid SCHEMBL8136526 | 0.94 | HTR1A (0.47) | MEN1KMT2AATMGAATRPV1 | |
| SCHEMBL8053407 | 0.86 | MEN1 (0.47) | MEN1KMT2AATMGAATRPV1 | |
| Hydrochloric Acid SCHEMBL8143284 | 0.85 | MEN1 (0.46) | MEN1KMT2AATMGAATRPV1 | |
| SCHEMBL7939820 | 0.74 | DRD2 (0.57) | MEN1KMT2AGAAHTR1ADRD2 | |
| SCHEMBL11884620 | 0.73 | PDE5A (0.39) | MEN1KMT2AGAA | |
| SCHEMBL7939857 | 0.72 | ALDH1A1 (0.47) | MEN1KMT2AHTR1ADRD2 | |
| SCHEMBL7939803 | 0.70 | CYP19A1 (0.37) | MEN1KMT2AGAA | |
| SCHEMBL8049534 | 0.70 | MEN1 (0.58) | MEN1KMT2AATMGAADRD2 | |
| SCHEMBL7933353 | 0.69 | DRD4 (0.50) | MEN1KMT2AHTR1ADRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053235-A1 | OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-11-22 | — | — | EP | claimed |
| WO-1999038864-A1 | OXAZOLE DERIVATIVES AS SEROTONIN-1A RECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-05 | — | — | WO | claimed |
| US-6057340-A | Oxazole derivatives as serotonin-1A receptor agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-05-02 | — | — | US | disclosed |