SCHEMBL8055002

SCHEMBL8055002

CN(C)c1cc(NS(=O)(=O)c2ccccc2)ncn1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMO O15229 1/20 0.52
ALDH1A1 P00352 3/20 0.47
KDM4E B2RXH2 2/20 0.47
HSD17B10 Q99714 2/20 0.47
HPGD P15428 1/20 0.47
CYP2C19 P33261 1/20 0.46
POLB P06746 1/20 0.46
TSHR P16473 3/20 0.44
MAPK1 P28482 2/20 0.44
TP53 P04637 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
ALOX15 P16050 1/20 0.44
LMNA P02545 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GAA P10253 2/20 0.44
PKM P14618 1/20 0.44
SLC40A1 Q9NP59 1/20 0.43
FFAR4 Q5NUL3 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4639507 0.90 MEN1 (0.50) KMOALDH1A1KDM4EHSD17B10HPGD
SCHEMBL8054964 0.87 CYP2C19 (0.51) ALDH1A1KDM4ECYP2C19MAPK1LMNA
SCHEMBL8056198 0.86 KMT2A (0.50) ALDH1A1CYP2C19TSHRFFAR4
SCHEMBL1136466 0.86 CYP2C19 (0.64) ALDH1A1KDM4ECYP2C19TSHRCYP3A4
SCHEMBL8058891 0.86 KDM4E (0.50) KMOALDH1A1KDM4ECYP2C19POLB
SCHEMBL7835681 0.85 LMNA (0.55) KMOLMNAPKMSLC40A1TNNI3K
Hydrochloric Acid SCHEMBL8054954 0.85 CYP2C19 (0.62) ALDH1A1KDM4ECYP2C19TSHRCYP3A4
SCHEMBL8056340 0.83 ALDH1A1 (0.59) ALDH1A1KDM4ECYP2C19POLBCYP1A2
SCHEMBL7836864 0.82 SLC40A1 (0.49) TSHRLMNAGAASLC40A1TNNI3K
SCHEMBL3434693 0.80 KDM4E (0.58) KMOALDH1A1KDM4EHSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6030976-A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE HOFFMAN-LA ROCHE INC. (US) 2000-02-29 US disclosed
US-5998665-A THERAPY FOR NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-12-07 US disclosed
US-5939451-A INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-08-17 US disclosed
US-5932599-A 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-08-03 US disclosed