SCHEMBL7836864

SCHEMBL7836864

CN(C)c1cc(NS(=O)(=O)c2cccc(C(F)(F)F)c2)ncn1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC40A1 Q9NP59 1/20 0.49
TSHR P16473 1/20 0.49
CA2 P00918 2/20 0.49
CA1 P00915 1/20 0.49
MMP1 P03956 1/20 0.49
MMP2 P08253 1/20 0.49
MMP9 P14780 1/20 0.49
MMP8 P22894 1/20 0.49
MMP13 P45452 1/20 0.49
CLK1 P49759 1/20 0.48
KDM1A O60341 1/20 0.47
HSD17B2 P37059 1/20 0.47
TNNI3K Q59H18 2/20 0.47
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
NR3C1 P04150 1/20 0.46
PGR P06401 1/20 0.46
AR P10275 1/20 0.46
ESR2 Q92731 1/20 0.46
GAA P10253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8055002 0.82 KMO (0.52) SLC40A1TSHRTNNI3KGAALMNA
SCHEMBL7835681 0.81 LMNA (0.55) SLC40A1TNNI3KPGRLMNA
Hydrochloric Acid SCHEMBL8055891 0.80 TSHR (0.57) SLC40A1TSHRCA2CA1MMP1
SCHEMBL8056340 0.78 ALDH1A1 (0.59) CA2CA1HSD17B2KMT2AMEN1
SCHEMBL8056198 0.77 KMT2A (0.50) TSHRKMT2A
SCHEMBL8054964 0.76 CYP2C19 (0.51) GAALMNA
SCHEMBL8058891 0.75 KDM4E (0.50) TNNI3KKMT2AMEN1GAALMNA
SCHEMBL1136466 0.75 CYP2C19 (0.64) TSHRKMT2AMEN1LMNANPSR1
SCHEMBL7824814 0.74 HTR6 (0.59) SLC40A1TSHRCA2CA1MMP1
SCHEMBL27430629 0.74 CA2 (0.62) SLC40A1TSHRCA2CA1MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0815861-B1 Sulphonamides and their use HOFFMANN LA ROCHE (CH) 2001-09-19 EP claimed
US-6030976-A SELECTIVE AFFINITY TO 5HT-6 RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS; ALZHEIMER'S DISEASE, PSYCHOSES, SCHIZOPHRENIA, MANIC DEPRESSIONS, MEMORY DISORDERS, PARKINSON'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS AND HUNTINGTON'S DISEASE HOFFMAN-LA ROCHE INC. (US) 2000-02-29 US disclosed
US-5998665-A THERAPY FOR NERVOUS SYSTEM DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-12-07 US disclosed
US-5939451-A INDOL-4-YL-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-08-17 US disclosed
US-5932599-A 4-AMINO-N-(PYRIDINYL-4-YL)-BENZENESULFONAMIDES AS ACTIVE MATERIAL TREATING MALARIA, BACTERIAL INFECTION, NEUROLOGICAL DISORDERS HOFFMANN-LA ROCHE INC. (US) 1999-08-03 US disclosed