Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.33 |
| ▸ | CA12 | O43570 | 4/20 | 0.33 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 4/20 | 0.33 |
| ▸ | CA9 | Q16790 | 4/20 | 0.33 |
| ▸ | METAP1 | P53582 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8055491 | 0.92 | CA12 (0.32) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL8038225 | 0.82 | KEAP1 (0.32) | MMP2CA12CA1CA2CA9 | |
| Cyclohexyl(Hydroxy)Methylenediphosphonic Acid SCHEMBL1674148 | 0.76 | FDPS (0.37) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL12076033 | 0.67 | FDPS (0.37) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL27864692 | 0.66 | LMNA (0.36) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL27792299 | 0.66 | MMP2 (0.37) | MMP2CA12CA1CA2CA9 | |
| SCHEMBL2931911 | 0.64 | CYP19A1 (0.34) | — | |
| SCHEMBL8049813 | 0.64 | LMNA (0.39) | FDPS | |
| SCHEMBL6352733 | 0.64 | MMP2 (0.37) | MMP2CA12CA1CA2CA9 | |
| Phosphoric Acid Monomethyl Ester SCHEMBL8076940 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563096-B1 | NOVEL METHYLENEBISPHOSPHONIC ACID DERIVATIVES | LEIRAS OY (FI) | 2000-05-03 | — | — | EP | disclosed |
| US-5438048-A | Used for treatment of disorders related to metabolism of calcium and other bivalent metals; treats bone cancer, urolithiasis, rheumatoid arthritis, bone infection and bone degradation | LEIRAS OY (FI) | 1995-08-01 | — | — | US | disclosed |