Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116829 | 0.72 | ADORA2B (0.33) | BRD4 | |
| SCHEMBL324388 | 0.66 | LMNA (0.58) | TSHR | |
| SCHEMBL8042371 | 0.62 | EGLN1 (0.33) | — | |
| SCHEMBL14467258 | 0.59 | APEX1 (0.50) | — | |
| SCHEMBL15581346 | 0.58 | KDM4E (0.33) | — | |
| SCHEMBL15033898 | 0.58 | PDE4A (0.45) | — | |
| SCHEMBL17832059 | 0.56 | TSHR (0.43) | TSHR | |
| SCHEMBL3522549 | 0.56 | ALDH1A1 (0.42) | BRD4 | |
| SCHEMBL14671613 | 0.55 | LMNA (0.39) | — | |
| SCHEMBL15581349 | 0.55 | KDM4E (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156811-A1 | Process for the Preparation of Bosentan | DIPHARMA FRANCIS S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156811-A1 | Process for the Preparation of Bosentan | PAH, HBB, HBZ | GFER 4085/4885TSHR 1453/4885BRD4 126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.