Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 8/20 | 0.37 |
| ▸ | MAOA | P21397 | 7/20 | 0.37 |
| ▸ | KDM1A | O60341 | 5/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL500727 | 1.00 | TAAR1 (0.46) | TAAR1TSHRMAPTMAOBMAOA | |
| SCHEMBL3354178 | 1.00 | TAAR1 (0.46) | TAAR1TSHRMAPTMAOBMAOA | |
| Dibenzofuran SCHEMBL28885932 | 0.86 | TAAR1 (0.37) | TAAR1TSHRMAPTMAOACYP2C9 | |
| SCHEMBL28563511 | 0.79 | KDM1A (0.37) | MAPTKDM1ACYP2C9LMNACYP3A4 | |
| SCHEMBL15842791 | 0.76 | TAAR1 (0.35) | TAAR1TSHRMAPT | |
| SCHEMBL15842834 | 0.74 | TAAR1 (0.33) | TAAR1TSHRMAPT | |
| SCHEMBL20385798 | 0.74 | HTR2C (0.46) | KDM1AHTR1AHTR2CDRD3RCOR1 | |
| SCHEMBL14044885 | 0.74 | HTR2C (0.45) | TAAR1KDM1ALMNAHTR2CADRA1A | |
| SCHEMBL28867385 | 0.72 | TAAR1 (0.51) | TAAR1TSHRMAOBMAOAKDM1A | |
| SCHEMBL20385738 | 0.72 | TAAR1 (0.51) | TAAR1TSHRMAOBMAOAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894299-B | Preparation method of axial chiral carbamate | 华南理工大学 | 2024-03-12 | — | — | CN | claimed |
| US-12492194-B2 | HPK1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-12-09 | — | — | US | disclosed |
| US-12486264-B2 | Bicyclic HPK1 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-12-02 | — | — | US | disclosed |
| EP-3947366-B1 | HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-21 | — | — | EP | disclosed |
| EP-3947373-B1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-05-14 | — | — | EP | disclosed |
| US-20220389157-A1 | PROCESS FOR POLYMERIZING BETA-BUTYROLACTONE | UNIV MUENCHEN TECH (DE) | 2022-12-08 | — | — | US | disclosed |
| US-20220177458-A1 | HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-09 | — | — | US | disclosed |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2022-06-02 | — | — | US | disclosed |
| EP-3974413-A1 | ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2022-03-30 | — | — | EP | disclosed |
| CN-105541925-B | Ferrocene frame having ferrocene frame N, N ligand and its preparation method and application | 中国人民解放军第四军医大学 | 2019-09-24 | — | — | CN | disclosed |
| CN-103003231-A | Novel method for preparing phenylcyclopropylamine derivatives and use thereof for preparing ticagrelor | ACTAVIS GROUP PTC EHF | 2013-03-27 | — | — | CN | disclosed |
| CN-102348703-A | Compounds for the treatment of metabolic disorders | PROSIDION LTD | 2012-02-08 | — | — | CN | disclosed |
| CN-1259322-C | Asymmetric copper compound and cyclopropanation reaction with it | SUMITOMO CHEMICAL CO (JP) | 2006-06-14 | — | — | CN | disclosed |
| CN-1384105-A | Asymmetric copper compound and cyclopropanation reaction with it | SUMITOMO CHEMICAL CO (JP) | 2002-12-11 | — | — | CN | disclosed |
| CN-1373116-A | Process for preparing optical active chrysanthemic acid | SUMITOMO CHEMICAL CO (JP) | 2002-10-09 | — | — | CN | disclosed |
| US-6011169-A | Process for producing optically active cyclopropanecaboxylic acid esters | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2000-01-04 | — | — | US | disclosed |
| EP-0891965-A1 | Process for producing optically active cyclopropanecarboxylic acid esters | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1999-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12486264-B2 | Bicyclic HPK1 inhibitors | PCK1, PGK1, PDXK | TAAR1 4646/4885TSHR 4507/4885MAPT 3982/4885 |
| US-20220389157-A1 | PROCESS FOR POLYMERIZING BETA-BUTYROLACTONE | CYP17A1, HSD17B7, COASY | TAAR1 4595/4885TSHR 4804/4885MAPT 1075/4885 |
| US-20220169644-A1 | BICYCLIC HPK1 INHIBITORS | PCK1, PGK1, PDXK | TAAR1 4646/4885TSHR 4507/4885MAPT 3982/4885 |
| US-20220177458-A1 | HPK1 INHIBITORS | PGK1, PCK1, PDXK | TAAR1 4709/4885TSHR 4497/4885MAPT 3343/4885 |
| US-12492194-B2 | HPK1 inhibitors | PGK1, PCK1, PDXK | TAAR1 4709/4885TSHR 4497/4885MAPT 3343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.