SCHEMBL8056783

SCHEMBL8056783

[CH2]Cc1ccc(C(=O)N(C)C)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.53
HPGD P15428 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
EPHX2 P34913 1/20 0.49
NR1H4 Q96RI1 1/20 0.49
ACACB O00763 1/20 0.44
PDK2 Q15119 4/20 0.42
PDK4 Q16654 3/20 0.42
PDK1 Q15118 2/20 0.42
PDK3 Q15120 2/20 0.42
HSD11B1 P28845 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
MMP2 P08253 1/20 0.41
MMP9 P14780 1/20 0.41
MMP8 P22894 1/20 0.41
ERN1 O75460 1/20 0.40
KMT2A Q03164 2/20 0.40
MAOB P27338 1/20 0.40
AOC3 Q16853 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1004649 0.82 ALDH1A1 (0.73) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL505778 0.81 ALDH1A1 (0.55) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL4485529 0.81 ALDH1A1 (0.59) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL16242064 0.81 ALDH1A1 (0.55) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL40709 0.80 ALDH1A1 (0.59) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL3757670 0.80 HPGD (0.58) ALDH1A1HPGDSMN1; SMN2KMT2AMEN1
SCHEMBL3818379 0.79 LOXL2 (0.55) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL3274471 0.79 CA1 (0.55) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL7223619 0.79 ALDH1A1 (0.53) ALDH1A1HPGDSMN1; SMN2EPHX2NR1H4
SCHEMBL12482466 0.79 NPSR1 (0.50) ALDH1A1HPGDACACBHDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9631048-B2 Sulfonium compounds, their preparation and use BASF SE (DE) 2017-04-25 US disclosed
CN-104379628-B Sulfonium compound, it prepares and application thereof 巴斯夫欧洲公司 2016-11-16 CN disclosed
EP-2838927-A2 SULFONIUM COMPOUNDS, THEIR PREPARATION AND USE BASF SE (DE) 2015-02-25 EP disclosed
CN-104379628-A Sulfonium compounds, their preparation and use BASF SE 2015-02-25 CN disclosed
US-20150044509-A1 SULFONIUM COMPOUNDS, THEIR PREPARATION AND USE BASF SE (DE) 2015-02-12 US disclosed
US-20140005301-A1 SULFONIUM SULFATES, THEIR PREPARATION AND USE BASF SE (DE) 2014-01-02 US disclosed
EP-2678311-A1 SULFONIUM SULFATES, THEIR PREPARATION AND USE BASF SE (DE) 2014-01-01 EP disclosed
WO-2013156509-A2 SULFONIUM COMPOUNDS, THEIR PREPARATION AND USE BASF SE (DE) 2013-10-24 WO disclosed
WO-2012113829-A1 SULFONIUM SULFATES, THEIR PREPARATION AND USE BASF SE (DE) 2012-08-30 WO disclosed
EP-1004304-A1 COMPOSITION CONTAINING ASCORBIC ACID SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2000-05-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150044509-A1 SULFONIUM COMPOUNDS, THEIR PREPARATION AND USE SQOR, ACSL3, ARSA ALDH1A1 573/4885HPGD 2808/4885SMN1; SMN2 3716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.