SCHEMBL8058715

SCHEMBL8058715

COc1cc(Oc2cccc(Cl)c2)nc(C(=O)O)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.43
CYP1A2 P05177 3/20 0.43
CYP2C19 P33261 3/20 0.43
CYP2C9 P11712 2/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
IGFBP3 P17936 1/20 0.42
HPGD P15428 2/20 0.41
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
GFER P55789 1/20 0.41
KMT2A Q03164 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
F2 P00734 1/20 0.41
F10 P00742 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP3A4 P08684 1/20 0.41
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41
AKR1C3 P42330 1/20 0.41
AKR1C2 P52895 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8070042 0.88 MAPT (0.50) CYP1A2CYP2C19CYP2C9L3MBTL1ALDH1A1
SCHEMBL8069129 0.85 OGG1 (0.45) CYP1A2CYP2C19CYP2C9L3MBTL1MEN1
SCHEMBL7108244 0.81 MAPT (0.48) MCL1HPGDF2F10ALDH1A1
SCHEMBL7049881 0.81 MAPT (0.63) CYP1A2CYP2C19CYP2C9L3MBTL1KMT2A
SCHEMBL987189 0.76 TDP1 (0.62) MCL1CYP1A2L3MBTL1HPGDLMNA
SCHEMBL8780576 0.76 MAPT (0.67) CYP1A2CYP2C19CYP2C9L3MBTL1SMN1; SMN2
SCHEMBL7113344 0.75 RORC (0.49) CYP1A2CYP2C19LMNAKDM4ERAB9A
SCHEMBL746177 0.73 TDP1 (0.55) MCL1L3MBTL1HPGDLMNAALDH1A1
SCHEMBL11412089 0.72 HRH3 (0.54) CYP1A2CYP2C19CYP2C9XDHSLC22A12
SCHEMBL8780575 0.72 EGLN1 (0.50) MCL1CYP1A2CYP2C19CYP2C9L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6159901-A 6-phenoxy picolinic acid alkylidene hydrazide derivative, process for producing the same and herbicide using the same KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-12-12 US disclosed
EP-1020444-A1 6-PHENOXYPICOLINIC ACID, ALKYLIDENEHYDRAZIDE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND HERBICIDE KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-07-19 EP disclosed