Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 0.47 |
| ▸ | THRB | P10828 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071065 | 0.89 | THRA (0.44) | THRATHRBPKMPOLBMAPT | |
| SCHEMBL8444218 | 0.85 | PKM (0.44) | THRATHRBPKMPOLBTTR | |
| Hydrochloric Acid SCHEMBL8070618 | 0.85 | SLC9A1 (0.44) | — | |
| Hydrochloric Acid SCHEMBL8073687 | 0.84 | PKM (0.43) | THRATHRBPKMPOLBTTR | |
| Hydrochloric Acid SCHEMBL8070615 | 0.83 | THRA (0.41) | THRATHRBPKMPOLBMAPT | |
| SCHEMBL8075422 | 0.83 | PKM (0.48) | THRATHRBPKMPOLBTTR | |
| Hydrochloric Acid SCHEMBL8070153 | 0.82 | PKM (0.47) | THRATHRBPKMPOLBTTR | |
| SCHEMBL8073825 | 0.81 | PKM (0.47) | THRATHRBPKMPOLBTTR | |
| SCHEMBL8073502 | 0.81 | TTR (0.51) | PKMPOLBTTRMAPT | |
| SCHEMBL8059726 | 0.80 | THRA (0.47) | THRATHRBTTRSLC6A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |
| EP-0723956-B1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AG (DE) | 1999-10-13 | — | — | EP | disclosed |
| EP-0723956-A1 | Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-07-31 | — | — | EP | disclosed |