Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 5/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061907 | 1.00 | OPRM1 (0.56) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL504205 | 1.00 | OPRM1 (0.56) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL6560350 | 0.89 | CYP2D6 (0.46) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL15154320 | 0.85 | CYP2D6 (0.43) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL9397304 | 0.84 | CYP2D6 (0.44) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL11600169 | 0.82 | CYP2D6 (0.51) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| Isoaminile SCHEMBL1642905 | 0.80 | EBP (0.52) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| Etaminile SCHEMBL2108910 | 0.79 | GRIN1 (0.50) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL11728209 | 0.79 | CYP2D6 (0.56) | OPRM1CYP2D6DRD4DRD3DRD2 | |
| SCHEMBL28302049 | 0.79 | CYP2D6 (0.56) | OPRM1CYP2D6DRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217919-A1 | NOVEL METHODS FOR SYNTHESIZING ENANTIOPURE (S)-METHADONE, (R)-METHADONE, RACEMIC (R,S)-METHADONE AND RELATED ANALOGUE SUBSTANCES | MANFREDI PAOLO L (US) | 2024-07-04 | — | — | US | disclosed |
| CN-117897146-A | Novel process for synthesizing enantiomerically pure (S) -methadone, (R) -methadone, racemic (R, S) -methadone and related analogues | 保罗·L·曼佛雷蒂 | 2024-04-16 | — | — | CN | disclosed |
| EP-4319733-A1 | NOVEL METHODS FOR SYNTHETIZING ENANTIOPURE (S)-METHADONE, (R)-METHADONE, RACEMIC (R,S)-METHADONE AND RELATED ANALOGUE SUBSTANCES | Manfredi, Paolo L. (US) | 2024-02-14 | — | — | EP | disclosed |
| US-11332434-B2 | Synthesis of levomethadone hydrochloride | SAFAEI GHOMI JAVAD (IR) | 2022-05-17 | — | — | US | disclosed |
| WO-2020212890-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE | SAFAEI GHOMI JAVAD (IR) | 2020-10-22 | — | — | WO | disclosed |
| US-20200277250-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE | SAFAEI GHOMI JAVAD (IR) | 2020-09-03 | — | — | US | disclosed |
| US-20190002394-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF | CODY LABORATORIES, INC. | 2019-01-03 | — | — | US | disclosed |
| US-10040752-B2 | Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof | CODY LABORATORIES, INC. (US) | 2018-08-07 | — | — | US | disclosed |
| EP-3341354-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF | Cody Laboratories, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035224-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF | CODY LABORATORIES, INC. (US) | 2017-03-02 | — | — | WO | disclosed |
| US-20170057909-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF | ALTER DOMUS (US) LLC | 2017-03-02 | — | — | US | disclosed |
| US-6143933-A | Process for the preparation of optically active methadones in high enantiomeric purity | SALFORD ULTRAFINE CHEMICALS & RESEARCH LTD. (GB) | 2000-11-07 | — | — | US | disclosed |
| EP-0914464-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE METHADONES IN HIGH ENANTIOMERIC PURITY | SALFORD ULTRAFINE CHEMICALS AND RESEARCH LIMITED (GB) | 1999-05-12 | — | — | EP | disclosed |
| WO-1997045551-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE METHADONES IN HIGH ENANTIOMERIC PURITY | SALFORD ULTRAFINE CHEMICALS & RESEARCH LIMITED (GB) | 1997-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240217919-A1 | NOVEL METHODS FOR SYNTHESIZING ENANTIOPURE (S)-METHADONE, (R)-METHADONE, RACEMIC (R,S)-METHADONE AND RELATED ANALOGUE SUBSTANCES | OPRM1, OPRD1, OPRK1 | OPRM1 1/4885CYP2D6 102/4885DRD4 46/4885 |
| US-20170057909-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF | CYP2D6, COMT, AADAT | OPRM1 35/4885CYP2D6 1/4885DRD4 119/4885 |
| US-20190002394-A1 | SYNTHESIS OF LEVOMETHADONE HYDROCHLORIDE OR DEXTROMETHADONE HYDROCHLORIDE AND METHODS FOR USE THEREOF | CYP2D6, COMT, AADAT | OPRM1 35/4885CYP2D6 1/4885DRD4 119/4885 |
| US-10040752-B2 | Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof | CYP2D6, COMT, AADAT | OPRM1 35/4885CYP2D6 1/4885DRD4 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.