Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | OGG1 | O15527 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11578734 | 0.78 | ACHE (0.47) | LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL11579347 | 0.78 | ACHE (0.52) | KMT2ADRD2DRD4LMNAHTT | |
| SCHEMBL11582756 | 0.77 | MAOB (0.46) | KMT2ALMNAMAPK1HTTKDM4E | |
| SCHEMBL1010862 | 0.75 | PPARA (0.38) | KMT2AKCNH2SLC6A4HTR2ADRD2 | |
| SCHEMBL507062 | 0.74 | CA4 (0.42) | SLC6A4 | |
| SCHEMBL8495864 | 0.74 | OGG1 (0.50) | KMT2AWDR5OGG1SMN1; SMN2KDM4E | |
| SCHEMBL30167806 | 0.74 | TP53 (0.59) | KMT2AKCNH2DRD2DRD4WDR5 | |
| SCHEMBL315808 | 0.74 | TP53 (0.59) | KMT2AKCNH2DRD2DRD4WDR5 | |
| SCHEMBL1583219 | 0.73 | ALDH1A1 (0.49) | KMT2ALMNAMAPK1HTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28211868 | 0.73 | LTA4H (0.40) | SLC6A4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000012522-A1 | MACROLIDE LHRH ANTAGONISTS | ABBOTT LABORATORIES (US) | 2000-03-09 | — | — | WO | disclosed |
| US-6020521-A | Macrolide LHRH antagonists | ABBOTT LABORATORIES (US) | 2000-02-01 | — | — | US | disclosed |
| US-4119729-A | TREATMENT OF HYPERTENSION | MEAD JOHNSON & COMPANY (US) | 1978-10-10 | — | — | US | disclosed |
| US-4067904-A | ANTIARRHYTHMIA, HYPOTENSIVE | MEAD JOHNSON & COMPANY (US) | 1978-01-10 | — | — | US | disclosed |