SCHEMBL8060201

SCHEMBL8060201

O=C(Oc1ccccc1)Oc1ccc(Cc2ccccc2)cc1

nearest known ligand 0.58

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 1/20 0.58
LTA4H P09960 5/20 0.53
PPARG P37231 3/20 0.53
PPARA Q07869 3/20 0.53
ELANE P08246 1/20 0.52
LMNA P02545 2/20 0.50
PLA2G10 O15496 1/20 0.50
PLA2G2A P14555 1/20 0.50
CALM1 P0DP23 1/20 0.48
MAPK1 P28482 1/20 0.47
CASP3 P42574 1/20 0.47
SENP7 Q9BQF6 1/20 0.47
SENP6 Q9GZR1 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CYP19A1 P11511 1/20 0.47
LIPE Q05469 1/20 0.47
FFAR1 O14842 1/20 0.46
ACACB O00763 1/20 0.46
ACACA Q13085 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5478152 0.98 LTA4H (0.55) SRD5A2LTA4HPPARGPPARAELANE
SCHEMBL28375781 0.91 SRD5A2 (0.50) SRD5A2LTA4HPPARGPPARAELANE
SCHEMBL28055585 0.87 ACHE (0.47) SRD5A2PPARGCALM1CYP19A1
SCHEMBL6224844 0.86 LTA4H (0.55) SRD5A2LTA4HPPARGPPARAELANE
SCHEMBL1624304 0.85 KMT2A (0.52) SRD5A2PPARGELANEL3MBTL1
SCHEMBL9220921 0.83 LMNA (0.49) SRD5A2LTA4HPPARGPPARALMNA
SCHEMBL8990079 0.83 ELANE (0.58) SRD5A2LTA4HPPARGPPARAELANE
SCHEMBL9353455 0.82 TDP1 (0.54) LTA4HPPARGELANEL3MBTL1CYP19A1
SCHEMBL9353461 0.82 TDP1 (0.54) LTA4HPPARGELANEL3MBTL1CYP19A1
SCHEMBL18073 0.82 TDP1 (0.54) LTA4HPPARGELANEL3MBTL1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9012676-B2 Processes for producing aryl carbamates, isocynates and polyureas using diaryl carbonate GREAT EASTERN RESINS INDUSTRIAL CO., LTD. (CN) 2015-04-21 US disclosed
US-20130079542-A1 PROCESSES FOR PRODUCING ARYL CARBAMATES, ISOCYNATES AND POLYUREAS USING DIARYL CARBONATE NATIONAL CHUNG HSING UNIVERSITY (TW) 2013-03-28 US disclosed
US-6143917-A FROM A DIARYL CARBONATE AND AN AMINE COMPOUND HAVING AT LEAST ONE HYDROGEN ATOM LOCATED AT AN N-POSITION UNDER MODERATE CONDITIONS AT A HIGH REACTION RATE WITH A HIGH SELECTIVITY AND WITH A HIGH YIELD UBE INDUSTRIES, LTD. (JP) 2000-11-07 US disclosed
EP-0902014-A1 PROCESS FOR PRODUCING ARYL CARBAMATES UBE INDUSTRIES LIMITED (JP) 1999-03-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130079542-A1 PROCESSES FOR PRODUCING ARYL CARBAMATES, ISOCYNATES AND POLYUREAS USING DIARYL CARBONATE UROD, DDC, TST SRD5A2 4014/4885LTA4H 4487/4885PPARG 461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.