Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116829 | 0.76 | ADORA2B (0.33) | HSD17B10ALDH1A1MAPK1KDM4ECYP1A2 | |
| SCHEMBL10667972 | 0.74 | KMT2A (0.42) | TSHRHSD17B10KMT2AALDH1A1LMNA | |
| SCHEMBL10376302 | 0.69 | HSD17B10 (0.43) | TSHRHSD17B10KMT2AALDH1A1LMNA | |
| SCHEMBL3828558 | 0.68 | TSHR (0.83) | TSHRKMT2AALDH1A1LMNAGFER | |
| SCHEMBL10374724 | 0.64 | HSD17B10 (0.39) | TSHRHSD17B10ALDH1A1LMNATHRB | |
| SCHEMBL7455602 | 0.64 | ALDH1A1 (0.43) | TSHRHSD17B10KMT2AALDH1A1LMNA | |
| SCHEMBL18851084 | 0.62 | TOP2A (0.38) | TSHRHSD17B10KMT2AALDH1A1MEN1 | |
| SCHEMBL14446910 | 0.62 | HSD17B10 (0.40) | TSHRHSD17B10KMT2AALDH1A1LMNA | |
| SCHEMBL1122732 | 0.61 | KDM4E (0.62) | KMT2AALDH1A1MAPK1MEN1KDM4E | |
| SCHEMBL5383922 | 0.60 | KMT2A (0.45) | TSHRHSD17B10KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156811-A1 | Process for the Preparation of Bosentan | DIPHARMA FRANCIS S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156811-A1 | Process for the Preparation of Bosentan | PAH, HBB, HBZ | TSHR 1453/4885HSD17B10 1031/4885KMT2A 1928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.