SCHEMBL8062830

SCHEMBL8062830

Cc1cc(C)cc(N(C)C(=O)C[C@@H](CC=O)c2ccc(Cl)c(Cl)c2)c1

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
SLC6A2 P23975 1/20 0.35
SLC6A4 P31645 1/20 0.35
SLC6A3 Q01959 1/20 0.35
LMNA P02545 1/20 0.34
HTT P42858 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CYP26A1 O43174 1/20 0.34
TACR1 P25103 1/20 0.34
GRM5 P41594 2/20 0.33
TACR2 P21452 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6969734 0.87 ALDH1A1 (0.49) ALDH1A1SLC6A2SLC6A4SLC6A3TACR1
SCHEMBL8063701 0.80 SLC6A3 (0.39) ALDH1A1SLC6A2SLC6A4SLC6A3LMNA
SCHEMBL8063574 0.77 TACR2 (0.48) TACR1TACR2
SCHEMBL8053254 0.77 TACR2 (0.48) TACR1TACR2
SCHEMBL7871985 0.77 SLC6A3 (0.44) ALDH1A1SLC6A2SLC6A4SLC6A3LMNA
SCHEMBL8062820 0.76 TACR1 (0.40) ALDH1A1LMNAHTTSMN1; SMN2CYP26A1
SCHEMBL8062825 0.76 TACR1 (0.40) ALDH1A1LMNAHTTSMN1; SMN2CYP26A1
SCHEMBL7811343 0.76 TACR1 (0.49) SLC6A4LMNAHTTTACR1TACR2
SCHEMBL8911597 0.76 PRKCZ (0.48) ALDH1A1LMNAHTTSMN1; SMN2CYP26A1
SCHEMBL4471203 0.74 TNF (0.48) ALDH1A1SLC6A2SLC6A4SLC6A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6013652-A ANTIINFLAMMATORY AGENTS; ANALGESICS; ANTIHISTAMINES MERCK & CO., INC. (US) 2000-01-11 US disclosed
US-5962462-A COMPOUNDS WHICH INHIBIT THE ENTRY OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INTO TARGET CELLS; DELAYING THE ONSET OF ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS). MERCK & CO., INC. (US) 1999-10-05 US disclosed
WO-1998025605-A1 SPIRO-SUBSTITUTED AZACYCLES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 1998-06-18 WO disclosed
EP-0702681-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO. INC. (US) 1996-03-27 EP disclosed
WO-1994029309-A1 SPIRO-SUBSTITUTED AZACYCLES AS NEUROKININ ANTAGONISTS MERCK & CO., INC. (US) 1994-12-22 WO disclosed