Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7728008 | 0.89 | SLC6A3 (0.49) | SLC6A3SLC6A2SLC6A4FFAR1SMN1; SMN2 | |
| SCHEMBL391563 | 0.85 | F2 (0.44) | SMN1; SMN2TSHRF10F2HTT | |
| SCHEMBL7728006 | 0.84 | FFAR1 (0.50) | SLC6A3SLC6A2SLC6A4FFAR1SMN1; SMN2 | |
| SCHEMBL7873751 | 0.83 | F10 (0.45) | SLC6A3SLC6A2SLC6A4FFAR1SMN1; SMN2 | |
| SCHEMBL7871902 | 0.83 | ALDH1A1 (0.41) | SLC6A3SLC6A2SLC6A4ALDH1A1MAPK1 | |
| SCHEMBL27962426 | 0.81 | F2 (0.45) | F10F2HTTALDH1A1LMNA | |
| SCHEMBL8771122 | 0.80 | SLC6A3 (0.49) | SLC6A3SLC6A2SLC6A4FFAR1SMN1; SMN2 | |
| SCHEMBL8911597 | 0.80 | PRKCZ (0.48) | FFAR1SMN1; SMN2TSHRHTTALDH1A1 | |
| SCHEMBL8063701 | 0.80 | SLC6A3 (0.39) | SLC6A3SLC6A2SLC6A4FFAR1SMN1; SMN2 | |
| SCHEMBL4471203 | 0.79 | TNF (0.48) | SLC6A3SLC6A2SLC6A4SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808303-B1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ASTRAZENECA AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0808303-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024582-A1 | 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1996-08-15 | — | — | WO | disclosed |