Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066636 | 0.90 | RAB9A (0.46) | RAB9A | |
| SCHEMBL8053617 | 0.90 | RAB9A (0.44) | RAB9AEPHX2 | |
| SCHEMBL4542096 | 0.87 | HTR1A (0.47) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8060221 | 0.85 | HTR1A (0.43) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8062526 | 0.85 | NPC1 (0.38) | RAB9AEPHX2 | |
| SCHEMBL8068354 | 0.85 | PSEN1 (0.47) | EPHX2 | |
| SCHEMBL8062528 | 0.85 | RAB9A (0.50) | RAB9A | |
| SCHEMBL8061501 | 0.84 | HSD11B1 (0.49) | — | |
| SCHEMBL8064947 | 0.84 | HTR1A (0.50) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL4537195 | 0.84 | HTR1A (0.50) | HTR1ADRD2HTR1DHTR1BHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |