Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8066441 | 0.90 | BDKRB1 (0.42) | RAB9A | |
| SCHEMBL4536848 | 0.86 | HTR1A (0.48) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8063759 | 0.85 | HTR1A (0.42) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8067674 | 0.84 | ALDH1A1 (0.46) | RAB9A | |
| SCHEMBL4533327 | 0.83 | HTR1A (0.52) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8068258 | 0.83 | EPHX2 (0.40) | EPHX2 | |
| SCHEMBL8064982 | 0.81 | HSD11B1 (0.45) | — | |
| SCHEMBL4542096 | 0.81 | HTR1A (0.47) | HTR1ADRD2HTR1DHTR1BHTR7 | |
| SCHEMBL8066519 | 0.80 | ALDH1A1 (0.35) | — | |
| SCHEMBL8068363 | 0.80 | HCRTR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |