Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999717 | 0.96 | LMNA (0.47) | LMNAPTGS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8999630 | 0.90 | HSP90AB1 (0.43) | LMNAPTGS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14356222 | 0.82 | KMT2A (0.53) | LMNAALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL217079 | 0.82 | CYP3A4 (0.56) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL223169 | 0.81 | PTGS2 (0.57) | LMNAPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL3927973 | 0.80 | GAA (0.53) | LMNAPTGS2ALDH1A1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL7327250 | 0.79 | PTGS2 (0.55) | LMNAPTGS2ALDH1A1MEN1KMT2A | |
| SCHEMBL9205800 | 0.78 | HSP90AB1 (0.50) | LMNAPTGS2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3914534 | 0.78 | ALDH1A1 (0.41) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL3924075 | 0.78 | ALOX15 (0.54) | LMNAALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6072046-A | SELECTIVELY FORM TRIPLEXES WITH A COMPLEMENTARY TARGET SEQUENCE IN DOUBLE-STRANDED DNA AND EFFICIENTLY CROSSLINK WITH BOTH STRANDS; THERAPEUTICS, DIAGNOSTICS, AND GENETIC PROBES | EPOCH PHARMACEUTICALS, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| WO-2000012523-A1 | DIAZIRIDINYL-ARYL AND BIS-[DI(CHLOROETHYL)AMINO]-ARYL OLIGONUCLEOTIDE CONJUGATES AND REAGENTS FOR MAKING THE SAME | EPOCH PHARMACEUTICALS, INC. (US) | 2000-03-09 | — | — | WO | disclosed |