Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 9/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 9/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP5 | P45974 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 2/20 | 0.39 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4537354 | 0.85 | EPHX1 (0.63) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL4535452 | 0.80 | EPHX2 (0.58) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL8064838 | 0.79 | EPHX1 (0.68) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL8053617 | 0.79 | RAB9A (0.44) | EPHX1EPHX2 | |
| SCHEMBL8063484 | 0.79 | EPHX2 (0.52) | EPHX1EPHX2HDAC6 | |
| SCHEMBL8066757 | 0.77 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1EPHX1EPHX2 | |
| SCHEMBL8069507 | 0.77 | MMP2 (0.46) | — | |
| SCHEMBL8061524 | 0.76 | EPHX2 (0.49) | EPHX1EPHX2HDAC6 | |
| SCHEMBL8066636 | 0.74 | RAB9A (0.46) | ALDH1A1 | |
| SCHEMBL8068354 | 0.74 | PSEN1 (0.47) | ALDH1A1L3MBTL1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | disclosed |