Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 4/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4540431 | 0.94 | NPC1 (0.55) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4537427 | 0.89 | SMN1; SMN2 (0.52) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4536776 | 0.88 | LMNA (0.62) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4539274 | 0.88 | CYP3A4 (0.51) | NPC1KMT2AEPHX1LMNATSHR | |
| SCHEMBL4535944 | 0.88 | EPHX1 (0.52) | RAB9AEPHX1LMNATSHRALOX12 | |
| SCHEMBL4542094 | 0.87 | NPC1 (0.57) | NPC1RAB9AKMT2ASMN1; SMN2EPHX1 | |
| SCHEMBL4535452 | 0.86 | EPHX2 (0.58) | EPHX1ALDH1A1EPHX2 | |
| SCHEMBL4542516 | 0.86 | LMNA (0.49) | KMT2AEPHX1LMNATSHRALOX12 | |
| SCHEMBL4540032 | 0.85 | PKM (0.51) | NPC1SMN1; SMN2EPHX1LMNATSHR | |
| SCHEMBL4537343 | 0.83 | LMNA (0.59) | KMT2ASMN1; SMN2EPHX1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070497-A1 | SEH AND 11 β-HSD1 INHIBITORS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-04 | — | — | WO | claimed |