Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 10/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3807183 | 0.83 | MAPT (0.44) | HTR1ADRD2HTR2AHTR6HTR7 | |
| SCHEMBL7913026 | 0.79 | PDE4B (0.43) | HTR7PDE4BPDE4D | |
| SCHEMBL8066070 | 0.77 | HTT (0.57) | KDM4ELMNAMAPTPOLB | |
| SCHEMBL8064800 | 0.76 | HTT (0.52) | PDE4BPDE4DALDH1A1MAPT | |
| SCHEMBL8068535 | 0.75 | HDAC7 (0.49) | PDE4BPDE4DALDH1A1 | |
| SCHEMBL8067208 | 0.75 | GRM2 (0.48) | ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL7904647 | 0.74 | PDE4D (0.40) | HTR7PDE4BPDE4DLMNAMAPT | |
| SCHEMBL8054760 | 0.74 | HDAC7 (0.55) | PDE4BKDM4ELMNAMAPTHPGD | |
| SCHEMBL8071515 | 0.73 | HDAC7 (0.45) | PDE4BPDE4DALDH1A1 | |
| SCHEMBL8066228 | 0.73 | HTT (0.48) | ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067600-A2 | BIARYL PDE4 INHIBITORS FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2009-05-28 | — | — | WO | disclosed |