Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071055 | 0.83 | ALDH1A1 (0.51) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL28296465 | 0.81 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL16419694 | 0.81 | GABRA1 (0.55) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL8608047 | 0.80 | PTGS2 (0.52) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL8059705 | 0.80 | CFTR (0.53) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL8070346 | 0.79 | PDGFRB (0.55) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL30280800 | 0.78 | CFTR (0.46) | KMT2AHPGDALDH1A1MAPTGAA | |
| SCHEMBL12121707 | 0.78 | GABRA1 (0.62) | GABRA1GABRG2GABRB3GABRA3EGFR | |
| SCHEMBL1920431 | 0.78 | CFTR (0.46) | KMT2AHPGDALDH1A1MAPTGAA | |
| SCHEMBL27656309 | 0.77 | PTGS2 (0.49) | GABRA1GABRG2GABRB3GABRA3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057322-A | USEFUL IN TREATMENT OF CARDIOVASCULAR DISEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |