Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | ADRB3 | P13945 | 12/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11071832 | 0.85 | ADRB2 (0.57) | KDM4EGAASMN1; SMN2ADRB3ADRB2 | |
| SCHEMBL9333215 | 0.85 | KDM4E (0.71) | KDM4EGAASMN1; SMN2TDP1ADRB3 | |
| SCHEMBL9332734 | 0.85 | KDM4E (0.71) | KDM4EGAASMN1; SMN2TDP1ADRB3 | |
| Hydrochloric Acid SCHEMBL11073162 | 0.84 | ADRB2 (0.56) | KDM4EGAASMN1; SMN2ADRB3ADRB2 | |
| Hydrochloric Acid SCHEMBL9333230 | 0.84 | KDM4E (0.70) | KDM4EGAASMN1; SMN2TDP1ADRB3 | |
| SCHEMBL9467878 | 0.80 | KDM4E (0.61) | KDM4EGAASMN1; SMN2TDP1ADRB3 | |
| SCHEMBL9332821 | 0.79 | ADRB3 (0.70) | KDM4EGAASMN1; SMN2TDP1ADRB3 | |
| SCHEMBL9333145 | 0.79 | ADRB3 (0.70) | KDM4EGAASMN1; SMN2TDP1ADRB3 | |
| SCHEMBL8067749 | 0.79 | MAPT (0.46) | GAASMN1; SMN2ADRB2 | |
| Hydrochloric Acid SCHEMBL9332705 | 0.78 | ALOX15 (0.70) | KDM4EGAASMN1; SMN2TDP1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028080-A | Quinolin-2-(1H)-ones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-02-22 | — | — | US | disclosed |
| EP-0885196-A1 | CHINOLINE-2-(1H)-ONES | MERCK PATENT GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997026244-A1 | CHINOLINE-2-(1H)-ONES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-07-24 | — | — | WO | disclosed |