Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15024786 | 0.98 | ADRA1D (0.46) | ADRA1DADRA1AADRA1BGAAPOLB | |
| SCHEMBL14865347 | 0.95 | POLB (0.49) | ADRA1DADRA1AADRA1BGAAPOLB | |
| SCHEMBL15024810 | 0.90 | RAB9A (0.43) | ADRA1DADRA1AADRA1BGAAPOLB | |
| SCHEMBL24621636 | 0.87 | NAAA (0.45) | ADRA1DADRA1AADRA1BGAAPOLB | |
| SCHEMBL15024716 | 0.86 | KMT2A (0.46) | GAAPOLBKMT2ATSHRRAB9A | |
| SCHEMBL29798956 | 0.84 | KMT2A (0.45) | ADRA1DADRA1AADRA1BPOLBKMT2A | |
| SCHEMBL15024707 | 0.84 | CYP1A2 (0.46) | ADRA1DADRA1AADRA1BGAAKMT2A | |
| SCHEMBL27984826 | 0.83 | POLB (0.47) | ADRA1DADRA1AADRA1BGAAPOLB | |
| SCHEMBL23343659 | 0.83 | KMT2A (0.44) | ADRA1DADRA1AADRA1BPOLBKMT2A | |
| SCHEMBL15024708 | 0.80 | ALDH1A1 (0.49) | GAAKMT2ATSHRALDH1A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035158-A1 | PYRAZINE DERIVATIVES AS ENAC BLOCKERS | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |