Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.33 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.32 |
| ▸ | KMO | O15229 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645380 | 0.74 | KDM4E (0.41) | KDM4EALDH1A1HPGD | |
| SCHEMBL6561118 | 0.72 | KDM4E (0.41) | KDM4EALDH1A1HPGDGAA | |
| SCHEMBL8069752 | 0.69 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL9692443 | 0.65 | KDM4E (0.44) | KDM4EALDH1A1HPGD | |
| SCHEMBL11697440 | 0.64 | SMN1; SMN2 (0.37) | KDM4EALDH1A1PKMPGK1VCAM1 | |
| SCHEMBL7659637 | 0.63 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGD | |
| SCHEMBL28468504 | 0.63 | HCAR3 (0.36) | — | |
| SCHEMBL8069868 | 0.63 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDPGK1SMN1; SMN2 | |
| SCHEMBL10979117 | 0.62 | MAPT (0.47) | KDM4EALDH1A1HPGDPGK1VCAM1 | |
| SCHEMBL8076721 | 0.62 | TLR3 (0.39) | ARMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071953-A | Sulfonamide-substituted chromans, processes for their preparation, their use as medicament or diagnostic aid, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-06-06 | — | — | US | disclosed |
| EP-0860440-A1 | Sulfonamido substituted chromane derivatives with potassium channel blocking activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-08-26 | — | — | EP | disclosed |